Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis-Reference-Cited by-同舟云学术

Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis

Published:2015 Issue:8 Volume:6 Page:4978-4985
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Goggins Sean¹²³⁴,Marsh Barrie J.⁵⁶⁴,Lubben Anneke T.¹²³⁴,Frost Christopher G.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Bath

3. Bath

4. UK

5. Atlas Genetics

6. Wiltshire

Abstract

An enzyme-triggered catalytic signal amplification cascade is described through the design of a novel enzyme substrate that selectively activates an organometallic transfer hydrogenation catalyst once triggered.

Funder

University of Bath

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC01588J

Reference63 articles.

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2. An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier

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4. Epinephrine: Cascade Reactions and Glycogenolytic Effect

5. G. Krauss , Biochemistry of Signal Transduction and Regulation, Wiley–VCH, Weinheim, 3rd edn, 2008, ch. 3, pp. 115–149

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