Alkaline phosphatase (ALP) activatable small molecule-based prodrugs for cancer theranostics-Reference-Cited by-同舟云学术

Alkaline phosphatase (ALP) activatable small molecule-based prodrugs for cancer theranostics

Published:2023 Issue:21 Volume:21 Page:4455-4464
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tyagi Kartikay¹,Kumari Reena¹,Venkatesh V.¹^ORCID

Affiliation:

1. Laboratory of Chemical Biology and Medicinal Chemistry, Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand-247667, India

Abstract

Alkaline phosphatase (ALP) activatable prodrugs are synthesized which exhibited improved selectivity, aqueous solubility, and anticancer potency compared to parent drug molecules.

Funder

Indian Institute of Technology Roorkee

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00510K

Reference36 articles.

1. Central and peripheral nervous system toxicity of common chemotherapeutic agents

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5. Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide

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