Structural identification of<i>in vitro</i>metabolites for 23-nordeoxycholic acid by structural analogue matching-Reference-Cited by-同舟云学术

Structural identification ofin vitrometabolites for 23-nordeoxycholic acid by structural analogue matching

Published:2023 Issue:21 Volume:15 Page:2588-2598
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Cao Yan¹²,Niu Xiaoya¹²,Li Wenzheng¹²,Chen Wei¹²,Ren Luyao¹²,Cao Zheng³,Li Jun¹²^ORCID,Song Yuelin¹^ORCID

Affiliation:

1. Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China

3. Center of Clinical Mass Spectrometry, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing 100026, China

Abstract

23-Nordeoxycholic acid was deployed to probe metabolism pathways of endogenous bile acids, and metabolite identification was achieved by applying the rule that C23–CH2defect quantitatively modifies both MS2spectrum and retention time features.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AY/D3AY00313B

Reference33 articles.

1. New insights into the bile acid-based regulatory mechanisms and therapeutic perspectives in alcohol-related liver disease

2. Bile acid metabolism and signaling, the microbiota, and metabolic disease

3. Ammonium fluoride-induced stabilization for anion attachment mass spectrometry: Facilitating the pseudotargeted profiling of bile acids submetabolome

4. Expanding the Scope of Targeted Metabolomics by One-pot Microscale Synthesis and Tailored Metabolite Profiling: Investigation of Bile Acid–Amino Acid Conjugates

5. Robust and Comprehensive Targeted Metabolomics Method for Quantification of 50 Different Primary, Secondary, and Sulfated Bile Acids in Multiple Biological Species (Human, Monkey, Rabbit, Dog, and Rat) and Matrices (Plasma and Urine) Using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Analysis