Highly enantioselective Ir/f-amphox-catalyzed hydrogenation of ketoamides: efficient access to chiral hydroxy amides-Reference-Cited by-同舟云学术

Highly enantioselective Ir/f-amphox-catalyzed hydrogenation of ketoamides: efficient access to chiral hydroxy amides

Published:2018 Issue:12 Volume:5 Page:2000-2003
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Hu Yang¹²³⁴⁵,Yin Xuguang¹²³⁴⁵,Chen Ziyi¹²³⁴⁵,Dong Xiu-Qin¹²³⁴⁵,Zhang Xumu¹²³⁴⁵^ORCID

Affiliation:

1. College of Chemistry and Molecular Sciences

2. Wuhan University

3. Wuhan

4. 430072

5. P. R. China

Abstract

Asymmetric synthesis of chiral hydroxy amides has been successfully accomplished by asymmetric hydrogenation of prochiral α-, β-, γ-, δ-keto amides catalyzed by Ir/f-amphox with up to >99% conversion and >99% ee.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00307F

Reference81 articles.

1. S. Hanessian , Total Synthesis of Natural Products: The Chiron Approach , Pergamon Press , New York , 1983 , ch. 2

2. α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists

3. G. M. Coppola and H. F.Schuster , α-Hydroxy Acids in Enantioselective Syntheses , VCH , Weinheim , 1997

4. Synthesis of the peptidic α-hydroxy amides phebestin, probestin, and bestatin from α-keto amide precursors

5. Concise Synthesis of Key Intermediate of Mirabegron via a Mixed Anhydride Method

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ate complexes in organic synthesis: From ate reagents to ate catalysts;Green Synthesis and Catalysis;2024-08

2. Chiral P,N,N‐Ligands for Asymmetric Hydrogenation;Advanced Synthesis & Catalysis;2024-04-24

3. Divergent Synthesis of β ‐Hydroxy Amides (Esters) and γ ‐Amino Alcohols via Ir/ f ‐Diaphos Catalyzed Asymmetric Hydrogenation;Advanced Synthesis & Catalysis;2022-08-05

4. Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives;Organic Letters;2022-04-01

5. Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation;Chemical Communications;2022