Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols <i>via</i> Ru-catalyzed asymmetric hydrogenation-Reference-Cited by-同舟云学术

Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation

Published:2022 Issue:91 Volume:58 Page:12696-12699
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wu Chao¹²,Ma Baode²^ORCID,Chen Gen-Qiang³^ORCID,Zhang Xumu²⁴^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, People's Republic of China

2. Shenzhen Grubbs Institute, Department of Chemistry, and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, 518055, China

3. Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518000, People's Republic of China

4. Shenzhen Bay Laboratory, Shenzhen, 518132, China

Abstract

We herein report a highly enantioselective hydrogenation of α-N-heteroaryl ketones catalyzed by chiral ruthenium catalysts, furnishing β-heteroaryl amino alcohols in superb yields and enantioselectivities (up to 99% yield and up to 99% ee).

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Guangdong Provincial Key Laboratory Of Catalysis

Shenzhen Municipal Science and Technology Innovation Council

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC03701G

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