Synthesis of novel <i>S</i>- and <i>O</i>-disaccharide analogs of heparan sulfate for heparanase inhibition-Reference-Cited by-同舟云学术

Synthesis of novel S- and O-disaccharide analogs of heparan sulfate for heparanase inhibition

Published:2022 Issue:17 Volume:20 Page:3528-3534
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Koffi Teki D. S.-E.¹,Coulibaly B.¹²,Bil A.¹,Vallin A.¹,Lesur D.¹,Fanté B.²,Chagnault V.¹^ORCID,Kovensky J.¹^ORCID

Affiliation:

1. Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A), UMR 7378 CNRS, Université de Picardie Jules Verne, 33 rue Saint Leu, F-80039 Amiens Cedex, France

2. Laboratoire de Constitution et Réaction de la Matière (LCRM), Université Félix Houphouët-Boigny (UFHB) de Cocody - Côte d'Ivoire, 22 BP 582 Abidjan 22, Côte d'Ivoire

Abstract

Design and synthesis of the first sulfated thiodisaccharide, analog of a heparane sulfate sequence, which is able to inhibit heparanase with an IC50 in the micromolar range.

Funder

Région Hauts-de-France

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00250G

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5. A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

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2. Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate;ACS Omega;2022-07-08