Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate

Author:

Meneghetti Maria C.Z.1,Naughton Lucy23,O’Shea Conor34,Koffi Teki Dindet S.-E.5ORCID,Chagnault Vincent5ORCID,Nader Helena B.1,Rudd Timothy R.67ORCID,Yates Edwin A.7,Kovensky José5,Miller Gavin J.34ORCID,Lima Marcelo A.23ORCID

Affiliation:

1. Departamento de Bioquímica, Instituto de Farmacologia e Biologia Molecular, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo 04044-020, São Paulo, Brazil

2. School of Life Sciences, Keele University, Keele ST55BG, Staffordshire, U.K.

3. Centre for Glycosciences, Keele University, Keele ST55BG, Staffordshire, U.K.

4. Lennard-Jones Laboratories, School of Chemical and Physical Sciences, Keele University, Keele ST55BG, Staffordshire, U.K.

5. Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A), UMR 7378 CNRS, Université de Picardie Jules Verne, 33 rue Saint Leu, Amiens Cedex F-80039, France

6. National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar EN6 3QG, Hertfordshire, U.K.

7. Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, U.K.

Funder

Royal Society

UK Research and Innovation

Academy of Medical Sciences

Wellcome Trust

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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