Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation
Author:
Affiliation:
1. Lead Discovery Siena srl
2. 53100 Siena
3. Italy
4. Dipartimento di Biotecnologie
5. Chimica e Farmacia
6. Università degli Studi di Siena
7. Fondazione Toscana Life Sciences
8. R&D Alfasigma S.p.A.
9. 00071 Pomezia
Abstract
A new weapon is added to the ADC arsenal, a thiol based HDAC inhibitor. Low toxic, hits the target and stops tumor growth in many mouse models.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC05266A
Reference35 articles.
1. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy
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4. The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers
5. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs)
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