A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides-Reference-Cited by-同舟云学术

A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides

Published:2024 Issue:16 Volume:15 Page:6168-6177
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ermini Elena¹^ORCID,Brai Annalaura¹^ORCID,Cini Elena¹^ORCID,Finetti Federica¹,Giannini Giuseppe²,Padula Daniele¹^ORCID,Paradisi Lucrezia¹,Poggialini Federica¹,Trabalzini Lorenza¹,Tolu Paola¹,Taddei Maurizio¹^ORCID

Affiliation:

1. Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy

2. Translational Medicine & Clinical Pharmacology Corporate R&D – Alfasigma SpA, Via Pontina, km 30400, 00071 Pomezia (Roma), Italy

Abstract

The power of pyrrole: a 1,6-self-immolative spacer designed on the pyrrole structure enables direct late-stage functionalisation of drugs and their traceless release under enzymatic or reductive micellar catalysis in water.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01576B

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