The synthesis and antibacterial activity study of ruthenium-based metallodrugs with a membrane-disruptive mechanism against <i>Staphylococcus aureus</i>-Reference-Cited by-同舟云学术

The synthesis and antibacterial activity study of ruthenium-based metallodrugs with a membrane-disruptive mechanism against Staphylococcus aureus

Published:2022 Issue:39 Volume:51 Page:14980-14992
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Chen Yushou¹,Liu Lianghong²,Wang Xuerong¹,Liao Zhouyuji¹,Wang Runbin¹,Xiong Yanshi¹,Cheng Jianxin¹,Jiang Guijuan¹,Wang Jintao¹^ORCID,Liao Xiangwen¹^ORCID

Affiliation:

1. Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, 330013, China

2. School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, 418000, China

Abstract

Ruthenium-based antibacterial agents with a membrane-disruptive mechanism were designed and synthesized. The complex Ru2 showed excellent antibacterial activity against S. aureus in vitro and in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Key Science and Technology Research Project in Jiangxi Province Department of Education

Jiangxi Science and Technology Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT01531E

Reference39 articles.