A two-step telescoped continuous flow switchable process leading to nitriles, diaziridine or hydrazine derivatives

Author:

Drageset Audun1234,Frøystein Nils Åge1234,Törnroos Karl Wilhelm1234ORCID,Bjørsvik Hans-René1234ORCID

Affiliation:

1. Department of Chemistry

2. University of Bergen

3. N-5007 Bergen

4. Norway

Abstract

Primary and benzylic alcohols were converted into nitriles on a continuous flow MJOD reactor platform or with a batch protocol. The two steps process involves TEMPO as the precatalyst with DIH and DCH as the terminal oxidants, respectively.

Funder

Universitetet i Bergen

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Reference47 articles.

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2. Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

3. Recent Advances in the Synthesis of Aryl Nitrile Compounds

4. K. Friedrich and K.Wallenfels , Chemistry of the Cyano Group , ed. Z. Rappoport , Wiley , London, U.K , 1970

5. A. J. Fatiadi , in Preparation and Synthetic Applications of Cyano Compounds , Wiley , New York , 1983

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