Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis-Reference-Cited by-同舟云学术

Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis

Published:2021 Issue:6 Volume:38 Page:1136-1220
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Alvarez Rosana¹²³⁴⁵^ORCID,de Lera Angel R.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Organic Chemistry and Center for Biomedical Research (CINBIO)

2. IBIV

3. Universidade de Vigo

4. 36310 Vigo

5. Spain

Abstract

Genetically-encoded polyenic macrolactams, which are constructed by Nature using hybrid polyketide synthase/nonribosomal peptide synthase (PKSs/NRPSs) assembly lines, are part of the large collection of natural products isolated from bacteria.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00050G

Reference247 articles.

1. Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles

2. Rare actinomycetes: a potential storehouse for novel antibiotics