A theoretical study on the activity and selectivity of IDO/TDO inhibitors-Reference-Cited by-同舟云学术

A theoretical study on the activity and selectivity of IDO/TDO inhibitors

Published:2024 Issue:23 Volume:26 Page:16747-16764
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Wujieti Baerlike¹^ORCID,Feng Xinping¹^ORCID,Liu Erxia¹,Li Deqing¹,Hao Mingtian¹^ORCID,Zhou Luqi¹,Cui Wei¹

Affiliation:

1. School of Chemical Sciences, University of Chinese Academy of Sciences, No. 19A, YuQuan Road, Beijing 100049, China

Abstract

This research constructed a complete process from enzyme (IDO/TDO) conformational activation to inhibitor binding/dissociation and used the thermodynamic and kinetic data as clues to verify the control mechanism of IDO/TDO on inhibitor selectivity.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CP/D3CP06036E

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