Endogenous kynurenines as targets for drug discovery and development
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd870.pdf
Reference146 articles.
1. Peters, J. C. Tryptophan nutrition and metabolism: an overview. Adv. Exp. Med. Biol. 294, 345–358 (1991).
2. Stone, T. W. & Perkins, M. N. Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur. J. Pharmacol. 72, 411–412 (1981).The original report of the neuroactive properties of quinolinic acid at NMDA receptors, and the trigger for the current widespread interest in the kynurenine pathway.
3. Schwarcz, R., Whetsell, W. O. Jr & Mangano, R. M. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219, 316–318 (1983).The first paper to show directly the neurotoxic activity of quinolinic acid in the CNS.
4. Perkins, M. N. & Stone, T. W. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247, 184–187 (1982).The first report of the ability of kynurenic acid to block glutamate receptors, including those for NMDA, kainate and quisqualate (used as an AMPA-receptor agonist before the discovery of metabotropic receptors).
5. Thomas, S. R. & Stocker, R. Redox reactions related to IDO and tryptophan metabolism along the kynurenine pathway. Redox Rep. 4, 199–220 (1999).
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