Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1” trimer siRNA
Author:
Affiliation:
1. Nano Medical Engineering Laboratory
2. RIKEN
3. Wako
4. Japan
5. Emergent Bioengineering Materials Research Team
6. RIKEN Center for Emergent Matter Science
Abstract
Nanostructured RNA carrying three different siRNAs was assembled to silence three target genes (Axin, APC, and GSK-3β) in the Wnt/β-catenin signaling pathway. This nanostructured ‘3-in-1’ siRNA showed high activity at a low concentration due to the long-term resistance, and enhancing the effect of RNA interference.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2017/TB/C7TB00846E
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