Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors-Reference-Cited by-同舟云学术

Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

Published:2020 Issue:3 Volume:56 Page:466-469
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kimura Yasuaki¹²³⁴⁵^ORCID,Shu Zhaoma¹²³⁴⁵,Ito Mika⁶⁷⁸⁹⁵,Abe Naoko¹²³⁴⁵^ORCID,Nakamoto Kosuke¹²³⁴⁵^ORCID,Tomoike Fumiaki¹⁰³⁴⁵^ORCID,Shuto Satoshi⁶⁷⁸⁹⁵^ORCID,Ito Yoshihiro¹¹¹²¹³⁵^ORCID,Abe Hiroshi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Graduate School of Science

3. Nagoya University

4. Nagoya 464-8602

5. Japan

6. Faculty of Pharmaceutical Sciences

7. Hokkaido University

8. Kita-12, Nishi-6, Kita-ku

9. Sapporo 060-0812

10. Research Center for Materials Science

11. Emergent Bioengineering Materials Research Team

12. RIKEN Center for Emergent Matter Science

13. Wako-Shi

Abstract

We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC04872C

Reference42 articles.

1. Molecular Mechanisms of RNA Interference

2. Interfering with disease: a progress report on siRNA-based therapeutics

3. Current prospects for RNA interference-based therapies

4. Chemical Modification of siRNA Bases To Probe and Enhance RNA Interference

5. Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

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