Cytosine methylation regulates DNA bendability depending on the curvature

Author:

Yeou Sanghun1ORCID,Hwang Jihee1,Yi Jaehun1,Kim Cheolhee2,Kim Seong Keun1ORCID,Lee Nam Ki1ORCID

Affiliation:

1. Department of Chemistry, Seoul National University, 08832, Seoul, Republic of Korea

2. National Science Museum, Daejeon, 34143, Republic of Korea

Abstract

D-shaped DNA is used to observe dsDNA bending mechanics. Cytosine methylation increases the intrinsic stiffness of dsDNA. Under strong bending, methylation stabilizes or destabilizes a kink form depending on methylation sites.

Funder

National Research Foundation of Korea

Seoul National University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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