MSAllstrategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra-Reference-Cited by-同舟云学术

MSAllstrategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra

Published:2017 Issue:22 Volume:142 Page:4279-4288
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Yin Lei¹²³⁴⁵^ORCID,Su Chong⁵⁶⁷⁸⁴,Ren Tianming⁵⁶⁷⁸⁴,Meng Xiangjun⁵⁶⁷⁸⁴,Shi Meiyun⁹¹⁰¹¹⁴,Paul Fawcett J.¹²¹³¹⁴¹⁵,Zhang Mengliang¹⁶¹⁷¹⁸¹⁹,Hu Wei¹²³⁴,Gu Jingkai¹²³⁴⁵^ORCID

Affiliation:

1. Research Institute of Translational Medicine

2. The First Hospital of Jilin University

3. Changchun 130061

4. PR China

5. Research Center for Drug Metabolism

6. School of Life Science

7. Jilin University

8. Changchun 130012

9. School of Life and Medical Sciences

10. Dalian University of Technology

11. New District of Liaodong Bay, Panjin124221

12. School of Pharmacy

13. University of Otago

14. Dunedin

15. New Zealand

16. Department of Chemistry

17. Middle Tennessee State University

18. Murfreesboro

19. USA

Abstract

Covalent attachment of PEG to therapeutic compounds (PEGylation) is one of the best techniques to improve the biological efficacy of small molecular weight drugs.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/AN/C7AN00470B

Reference47 articles.

1. Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tartrate Delivery Systems

2. Anti-cancer PEG-enzymes: 30 years old, but still a current approach

3. PEGylation, successful approach to drug delivery

4. Effect of pegylation on pharmaceuticals

5. Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy

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