Total syntheses of <i>Ganoderma</i>-derived meroterpenoids, (−)-oregonensin A, (−)-chizhine E, (−)-applanatumol U, and (−)-<i>ent</i>-fornicin A-Reference-Cited by-同舟云学术

Total syntheses of Ganoderma-derived meroterpenoids, (−)-oregonensin A, (−)-chizhine E, (−)-applanatumol U, and (−)-ent-fornicin A

Published:2022 Issue:46 Volume:20 Page:9138-9141
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hori Kazuki¹,Kamo Shogo¹^ORCID,Sugita Kazuyuki¹^ORCID

Affiliation:

1. Department of Synthetic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

Total syntheses of four Ganoderma-derived meroterpenoids have been achieved with the longest linear sequence of 6–8 steps and in 21–36% overall yield by using reductive lactonization, alkylation, and sulfoxide-β-syn-elimination as key steps.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01839J

Reference29 articles.

1. Ganoderma – A therapeutic fungal biofactory

2. Secondary metabolites from Ganoderma

3. Meroterpenoids from Ganoderma Species: A Review of Last Five Years

4. Total Synthesis of Cochlearol B via Intramolecular [2+2] Photocycloaddition

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