A covalently conjugated branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery

Author:

Li Runze1,Wu Xiaohui23,Li Jing1,Lu Xuehe2,Zhao Robert Chunhua14,Liu Jianbing23ORCID,Ding Baoquan23ORCID

Affiliation:

1. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Dongdan Santiao No. 5, Beijing 100005, China

2. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for NanoScience and Technology, 11 BeiYiTiao, ZhongGuanCun, Beijing 100190, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. School of Life Sciences, Shanghai University, Shanghai 200444, China

Abstract

A covalently conjugated branched DNA aptamer cluster-based nanoplatform was designed for efficiently targeted drug delivery to inhibit the proliferation of tumor cells.

Funder

National Key Research and Development Program of China

Chinese Academy of Sciences

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Natural Science Foundation of China

K. C. Wong Education Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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