P(NMe2)3 mediated cyclopropanation of α-methylene-β-lactams for rapid syntheses of spirocyclopropyl β-lactams-Reference-Cited by-同舟云学术

P(NMe2)3 mediated cyclopropanation of α-methylene-β-lactams for rapid syntheses of spirocyclopropyl β-lactams

Published:2020 Issue:24 Volume:18 Page:4599-4603
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Luo Si-Qin¹²³⁴,Liu Wei¹²³⁴,Ruan Ban-Feng¹²³⁴,Fan Shi-Lu⁵²⁶⁴^ORCID,Zhu Hui-Xia¹²³⁴,Tao Wei¹²³⁴,Xiao Hua¹²³⁴⁷^ORCID

Affiliation:

1. Department of Pharmaceutical Engineering

2. Hefei University of Technology

3. Hefei 230601

4. China

5. Department of Chemistry

6. Hefei

7. Key Laboratory of Synthetic Chemistry of Natural Substances

Abstract

A P(NMe₂)₃-promoted cyclopropanation of a C3-substituted α-methylene-β-lactam provides a rapid and user-friendly method to obtain pharmaceutically intriguing spirocyclopropyl β-lactams under mild reaction conditions.

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00826E

Reference34 articles.

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4. Spirocyclopropyl β-Lactams as Mechanism-Based Inhibitors of Serine β-Lactamases. Synthesis by Rhodium-Catalyzed Cyclopropanation of 6-Diazopenicillanate Sulfone

5. Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

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