Enantioselective synthesis of cis-hexahydro-γ-carboline derivatives via Ir-catalyzed asymmetric hydrogenation-Reference-Cited by-同舟云学术

Enantioselective synthesis of cis-hexahydro-γ-carboline derivatives via Ir-catalyzed asymmetric hydrogenation

Published:2022 Issue:20 Volume:58 Page:3286-3289
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zheng Long-Sheng¹,Yin Congcong¹,Wang Fangyuan¹,Chen Gen-Qiang²^ORCID,Zhang Xumu¹^ORCID

Affiliation:

1. Medi-X Pingshan, Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, 518000, People's Republic of China

2. Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518000, People's Republic of China

Abstract

A novel synthetic protocol was developed for the construction of chiral cis-hexahydro-γ-carboline derivatives through Ir/ZhaoPhos-catalyzed asymmetric hydrogenation with up to 99% yield, up to > 99 : 1 dr, and up to 99% ee.

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

Special Project for Research and Development in Key areas of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC06888A

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