Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitors-Reference-Cited by-同舟云学术

Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitors

Published:2015 Issue:2 Volume:6 Page:283-299
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Farag Doaa Boshra¹²³⁴⁵,Farag Nahla A.¹²³⁴⁵,Esmat Ahmed⁶²⁷⁴⁵,Abuelezz Sally A.⁸⁹⁷⁴⁵,Abdel-Salam Ibrahim Eman¹⁰⁹⁷⁴⁵,Abou El Ella Dalal A.¹²⁷⁴⁵

Affiliation:

1. Pharmaceutical Chemistry Department

2. Faculty of Pharmacy

3. Misr International University

4. Cairo

5. Egypt

6. Pharmacology & Toxicology Department

7. Ain Shams University

8. Pharmacology & Therapeutics Department

9. Faculty of Medicine

10. Pathology Department

Abstract

Four novel series of quinazoline derivatives IIIa–c, VIa–c and their NO-hybrid molecules as nitrate esters Va–c and VIIIa–c have been synthesized and evaluated for their anti-inflammatory activity in vivo and in vitro.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00392F

Reference48 articles.

1. Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib

2. Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides

3. Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors

4. Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors

5. Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors

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