A traction force threshold signifies metastatic phenotypic change in multicellular epithelia-Reference-Cited by-同舟云学术

A traction force threshold signifies metastatic phenotypic change in multicellular epithelia

Published:2019 Issue:36 Volume:15 Page:7203-7210
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Zhang Yao¹²³⁴^ORCID,Shi Xuechen⁵²³⁴,Zhao Tiankai¹²³⁴,Huang Changjin¹²³⁴,Wei Qiong¹²³⁴,Tang Xin⁶⁷⁸⁴,Santy Lorraine C.⁹²³⁴,Saif M. Taher A.¹⁰¹¹¹²⁴,Zhang Sulin¹²³⁴⁵

Affiliation:

1. Department of Engineering Science and Mechanics

2. The Pennsylvania State University

3. University Park

4. USA

5. Department of Biomedical Engineering

6. Department of Mechanical and Aerospace Engineering

7. University of Florida

8. Gainesville

9. Department of Biochemistry and Molecular Biology

10. Department of Mechanical Science and Engineering

11. The University of Illinois

12. Urbana

Abstract

Using extracellular matrix control of cellular mechanics, we establish that cellular force threshold can also mark in vitro metastatic phenotypic change and malignant transformation in HCT-8 cell colonies.

Funder

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SM/C9SM00733D

Reference41 articles.

1. Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

2. Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling