Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Author:

Baghdadi Neazar E.12345ORCID,Burke Benjamin P.6789,Alresheedi Tahani510896,Nigam Shubhanchi510896,Saeed Abdu11122134ORCID,Almutairi Farooq5108914,Domarkas Juozas510896,Khan Abid678915,Archibald Stephen J.510896ORCID

Affiliation:

1. Centre of Nanotechnology

2. King Abdul-Aziz University

3. Jeddah

4. Saudi Arabia

5. Department of Chemistry

6. Department of Biomedical Sciences and PET Research Centre

7. University of Hull Cottingham Road

8. Hull

9. UK

10. University of Hull

11. Department of Physics

12. Faculty of Science

13. Jeddah 21589

14. College of Applied Medical Sciences

15. Division of Pharmacy and Optometry

Abstract

Superparamagnetic iron oxide nanoparticles have been coated with a low affinity CXCR4 receptor antagonist to give a high affinity multivalent CXCR4 binding construct.

Funder

University of Hull

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference33 articles.

1. B. P. Burke , C.Cawthorne and S. J.Archibald , in Clinical Applications of Magnetic Nanoparticles: From Fabrication to Clinical Applications , ed. N. T. K. Thanh , CRC Press , 2018 , ch. 23, pp. 409–428

2. Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

3. Nanoparticle multivalency counterbalances the ligand affinity loss upon PEGylation

4. Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

5. MRI and PET/MRI in hematologic malignancies

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