<i>trans</i>-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors-Reference-Cited by-同舟云学术

trans-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors

Published:2024 Issue:12 Volume:53 Page:5616-5623
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Alzahrani Seraj O.¹,McRobbie Graeme¹,Khan Abid¹²,D'huys Thomas³,Van Loy Tom³,Walker Ashlie N.⁴,Renard Isaline¹⁵^ORCID,Hubin Timothy J.⁴^ORCID,Schols Dominique³,Burke Benjamin P.¹,Archibald Stephen J.¹⁵^ORCID

Affiliation:

1. Centre for Biomedicine and Positron Emission Tomography Research Centre, Hull York Medical School and University of Hull, Cottingham Road, Hull, HU6 7RX, UK

2. The University of Manchester, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester, UK

3. KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium

4. Department of Chemistry and Physics, Southwestern Oklahoma State University, Weatherford, OK 73096, USA

5. School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor Lambeth Wing, St Thomas’ Hospital, London, SE1 7EH, UK

Abstract

Alkylation of secondary amines on side-bridged cyclam derivatives locks the resulting metal complex in the trans-IV configuration. These derivatives offer new perspectives for the design and development of CXCR4-targeted therapeutic agents.

Funder

Yorkshire Cancer Research

KU Leuven

University of Hull

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D3DT01729J

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