Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms-Reference-Cited by-同舟云学术

Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms

Published:2017 Issue:4 Volume:17 Page:681-690
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Shirure V. S.¹²³^ORCID,George S. C.¹²³⁴²

Affiliation:

1. Department of Biomedical Engineering

2. Washington University in St. Louis

3. USA

4. Department of Energy, Environment, and Chemical Engineering

Abstract

We characterized the dynamics of drug-loss in microfluidics, and provide a quantitative framework for the design of organ-on-a-chip for drug discovery.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2017/LC/C6LC01401A

Reference19 articles.

1. Microfluidic organs-on-chips

2. A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

3. Formation of microvascular networks in vitro

4. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

5. Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

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