Exploring the potential of gold(iii) cyclometallated compounds as cytotoxic agents: variations on the C^N theme-Reference-Cited by-同舟云学术

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Exploring the potential of gold(iii) cyclometallated compounds as cytotoxic agents: variations on the C^N theme

Published:2015 Issue:26 Volume:44 Page:11911-11918
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Bertrand B.¹²³⁴⁵,Spreckelmeyer S.¹²³⁴⁵,Bodio E.⁶⁷⁸⁹,Cocco F.¹⁰¹¹¹²¹³,Picquet M.⁶⁷⁸⁹,Richard P.⁶⁷⁸⁹,Le Gendre P.⁶⁷⁸⁹,Orvig C.¹⁴¹⁵¹⁶¹⁷¹⁸,Cinellu M. A.¹⁰¹¹¹²¹³,Casini A.¹²³⁴⁵

Affiliation:

1. Dept. Pharmacokinetics

2. Toxicology and Targeting

3. Research Institute of Pharmacy

4. University of Groningen

5. 9713 AV Groningen

6. ICMUB UMR6302

7. CNRS, Univ. Bourgogne Franche-Comté

8. F-21000 Dijon

9. France

10. Università degli Studi di Sassari

11. Dipartimento di Chimica e Farmacia

12. Sassari

13. Italy

14. Medicinal Inorganic Chemistry Group

15. Department of Chemistry

16. University of British Columbia

17. Vancouver

18. Canada

Abstract

New (C^N) cyclometallated Au(iii) complexes with cytotoxic properties shown to be potent inhibitors of the zinc finger protein PARP-1.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C5DT01023C

Reference34 articles.

1. Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode

2. Metallodrugs in Medicinal Inorganic Chemistry

3. The status of platinum anticancer drugs in the clinic and in clinical trials

4. Insights into the Reactivity of Gold-Dithiocarbamato Anticancer Agents toward Model Biomolecules by Using Multinuclear NMR Spectroscopy

5. On the medicinal chemistry of gold complexes as anticancer drugs

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