How a few help all: cooperative crossing of lipid membranes by COSAN anions

Author:

Malaspina David C.1ORCID,Teixidor Francesc1ORCID,Viñas Clara1ORCID,Faraudo Jordi1ORCID

Affiliation:

1. Institut de Ciencia de Materials de Barcelona, ICMAB-CSIC, Campus de la UAB, E- 08193, Bellaterra, Spain

Abstract

COSAN anions are able to efficiently cross bilayers impermeable to ions due to a cooperative flip-flop mediated by transient, elongated structures within the membrane, implying a novel ion permeation mechanism with self-assembly characteristics.

Funder

Agencia Estatal de Investigación

H2020 Marie Skłodowska-Curie Actions

Agència de Gestió d'Ajuts Universitaris i de Recerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference37 articles.

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2. Molecular Simulation of the Transport of Drugs across Model Membranes

3. Oxygen permeability of phosphatidylcholine--cholesterol membranes.

4. Permeability of small nonelectrolytes through lipid bilayer membranes

5. Microsecond Molecular Dynamics Simulations of Lipid Mixing

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