Compelling DNA intercalation through ‘anion–anion’ anti-coulombic interactions: boron cluster self-vehicles as promising anticancer agents-Reference-Cited by-同舟云学术

Compelling DNA intercalation through ‘anion–anion’ anti-coulombic interactions: boron cluster self-vehicles as promising anticancer agents

Published:2024 Issue: Volume: Page:
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Gutiérrez-Gálvez Laura¹,García-Mendiola Tania¹²^ORCID,Lorenzo Encarnación¹²³,Nuez-Martinez Miquel⁴,Ocal Carmen⁴^ORCID,Yan Shunya⁴,Teixidor Francesc⁴^ORCID,Pinheiro Teresa⁵⁶^ORCID,Marques Fernanda⁶⁷^ORCID,Viñas Clara⁴^ORCID

Affiliation:

1. Departamento de Química Analítica y Análisis Instrumental, Universidad Autónoma de Madrid, 28049, Madrid, Spain

2. Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049, Madrid, Spain

3. IMDEA-Nanociencia, Ciudad Universitaria de Cantoblanco, 28049, Madrid, Spain

4. Institut de Ciència de Materials de Barcelona (C.S.I.C.) Campus U.A.B, 08193 Bellaterra, Barcelona, Spain

5. iBB – Instituto de Bioengenharia e Biociências, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal

6. Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal

7. C2TN – Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela LRS, Portugal

Abstract

The amphiphilic anionic ferrabis(dicarbollide) boron-rich small molecule effectively penetrates the nucleus as a carrier-free drug and intercalates with ds-DNA base pairs, making it a promising candidate for multimodal cancer radiotherapy.

Funder

Generalitat de Catalunya

Ministerio de Universidades

China Scholarship Council

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB01177E

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