Palladium-catalyzed decarbonylative methylation of aryl carboxylic acids

Author:

Feng Boya1ORCID,Zhang Guodong1,Feng Xu1,Chen Yu12ORCID

Affiliation:

1. Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China

2. Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, 210014, China

Abstract

Described herein is a palladium-catalyzed decarbonylative methylation of general carboxylic acids, providing an efficient method for Ar–Me bond formation.

Funder

Jiangsu Forestry Bureau

National Natural Science Foundation of China

Jiangsu Key Laboratory for the Research and Utilization of Plant Resources

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference51 articles.

1. The Methylation Effect in Medicinal Chemistry

2. Intramolecular Charge Transfer Controls Switching Between Room Temperature Phosphorescence and Thermally Activated Delayed Fluorescence

3. M. H.Qureshi and J. T.Njardarson , Top 200 Small Molecule Pharmaceuticals by Retail Sales in 2020. https://njardarson.lab.arizona.edu/sites/njardarson.lab.arizona.edu/files/Top%20200%20Pharmaceuticals%20Small%20Molecule%202020V3.pdf

4. Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

5. Methyl-containing pharmaceuticals: Methylation in drug design

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