Phenyl-guanidine derivatives as potential therapeutic agents for glioblastoma multiforme: catalytic syntheses, cytotoxic effects and DNA affinity-Reference-Cited by-同舟云学术

Phenyl-guanidine derivatives as potential therapeutic agents for glioblastoma multiforme: catalytic syntheses, cytotoxic effects and DNA affinity

Published:2016 Issue:10 Volume:6 Page:8267-8276
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bravo I.¹²³⁴⁵,Alonso-Moreno C.⁶⁷²³⁴,Posadas I.⁸⁹³²⁴,Albaladejo J.¹²¹⁰¹¹¹²,Carrillo-Hermosilla F.⁶⁷²¹⁰¹¹,Ceña V.⁸⁹¹³²⁴,Garzón A.¹²³⁴⁵,López-Solera I.⁶⁷²¹⁰¹¹,Romero-Castillo L.⁸⁹³²⁴

Affiliation:

1. Departamento de Química-Física

2. Universidad de Castilla-La Mancha

3. Facultad de Farmacia

4. Campus Universitario de Albacete

5. 02071-Albacete

6. Departamento de Química Inorgánica

7. Orgánica y Bioquímica

8. Unidad Asociada Neurodeath CSIC-UCLM

9. Departamento de Ciencias Médicas

10. Facultad de Ciencias y Tecnologías Químicas

11. Campus Universitario de Ciudad Real

12. 13071-Ciudad Real

13. Facultad de Medicina

Abstract

Glioblastoma is a highly malignant form of brain tumor. In the work described here, several substituted phenyl-guanidine derivatives were developed for application in glioblastoma treatment.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA17920C

Reference67 articles.

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4. Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology33Abbreviations: MIBG, m-iodobenzylguanidine; MGBG, methylglyoxal bis(guanylhydrazone); MIBA, m-iodobenzylamine; BG, benzylguanidine; NE, norepinephrine; GBG, glyoxal bis(guanylhydrazone); EGBG, ethylglyoxal bis(guanylhydrazone); MGBCP, methylglyoxal bis(cyclopentylamidinohydrazone); ODC, ornithine decarboxylase; and SAMDC, S-adenosylmethionine decarboxylase.

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