Taking control of P1, P1′ and double bond stereochemistry in the synthesis of Phe-Phe (E)-alkene amide isostere dipeptidomimetics
Author:
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2007/OB/B616906F
Reference35 articles.
1. Methyl- and (Trifluoromethyl)alkene Peptide Isosteres: Synthesis and Evaluation of Their Potential as β-Turn Promoters and Peptide Mimetics
2. Diastereoselective Synthesis of New ψ[(E)-CHCMe]- and ψ[(Z)-CHCMe]-type Alkene Dipeptide Isosteres by Organocopper Reagents and Application to Conformationally Restricted Cyclic RGD Peptidomimetics
3. Peptide Bond Isosteres: Ester or (E)-Alkene in the Backbone of the Collagen Triple Helix
4. Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides
5. Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosteres To Probe Structural Requirements of the Peptide Transporter PEPT1
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