Biologically active [Pd2L4]4+ quadruply-stranded helicates: stability and cytotoxicity
Author:
Affiliation:
1. Department of Pharmacology and Toxicology
2. University of Otago
3. Dunedin
4. New Zealand
5. Department of Chemistry
Abstract
A quadruply-stranded dipalladium(ii) helicate exhibits low micromolar IC50 values against a range of different cancer cell lines. Preliminary mechanistic studies indicate that the helicate induces cell death by disrupting the cell membrane.
Funder
Otago Medical Research Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/DT/C5DT01259G
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