Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity-Reference-Cited by-同舟云学术

Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity

Published:2017 Issue:9 Volume:8 Page:1856-1862
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Konč Juraj¹²³⁴,Tichý Michal¹²³⁴^ORCID,Pohl Radek¹²³⁴,Hodek Jan¹²³⁴,Džubák Petr⁵⁶⁷⁸⁴,Hajdúch Marián⁵⁶⁷⁸⁴,Hocek Michal¹²³⁴⁹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry

2. Czech Academy of Sciences

3. CZ-16610 Prague 6

4. Czech Republic

5. Institute of Molecular and Translational Medicine

6. Palacky University and University Hospital in Olomouc

7. Faculty of Medicine and Dentistry

8. CZ-775 15 Olomouc

9. Department of Organic Chemistry

Abstract

Sugar-modified pyrimido[4,5-b]indole nucleosides (2′-deoxy-2′-fluororibo-, 2′-deoxy-2′-fluoroarabino- and arabinonucleosides) were found to be low micromolar antivirals against HCV or dengue.

Funder

Czech Science Foundation

Akademie ved Ceské Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00319F

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