Synthesis and characterization of thiocarbonato-linked platinum(iv) complexes

Author:

Barth Marie-Christin1ORCID,Lange Stefanie2,Häfner Norman2ORCID,Ueberschaar Nico3ORCID,Görls Helmar1,Runnebaum Ingo B.2,Weigand Wolfgang1ORCID

Affiliation:

1. Department of Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Humboldtstrasse 8, 07743 Jena, Germany

2. Department of Gynecology and Reproduction Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany

3. Mass Spectrometry Platform, Friedrich Schiller University Jena, Humboldtstrasse 8, 07743 Jena, Germany

Abstract

Novel platinum(iv) complexes with thiocarbonate linkage were synthesized and their cytotoxic activity against ovarian carcinoma cell lines was investigated. Insights into the reaction with ascorbic acid were provided by UHPLC-HRMS.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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