Octahedral copper(ii)-diimine complexes of triethylenetetramine: effect of stereochemical fluxionality and ligand hydrophobicity on CuII/CuIredox, DNA binding and cleavage, cytotoxicity and apoptosis-inducing ability-Reference-Cited by-同舟云学术

Octahedral copper(ii)-diimine complexes of triethylenetetramine: effect of stereochemical fluxionality and ligand hydrophobicity on CuII/CuIredox, DNA binding and cleavage, cytotoxicity and apoptosis-inducing ability

Published:2020 Issue:24 Volume:49 Page:8282-8297
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sharma Mitu¹²³⁴^ORCID,Ganeshpandian Mani⁵⁶⁷⁴^ORCID,Majumder Munmi⁸²³⁴,Tamilarasan Ajaykamal⁹¹⁰¹¹⁴^ORCID,Sharma Mukesh¹²³⁴^ORCID,Mukhopadhyay Rupak⁸²³⁴^ORCID,Islam Nashreen S.¹²³⁴^ORCID,Palaniandavar Mallayan⁹¹⁰¹¹⁴^ORCID

Affiliation:

1. Department of Chemical Sciences

2. Tezpur University

3. Tezpur 784 028

4. India

5. Department of Chemistry

6. SRM Institute of Science & Technology

7. Chennai 603 203

8. Department of Molecular Biology and Biotechnology

9. School of Chemistry

10. Bharathidasan University

11. Tiruchirappalli 620 024

Abstract

Stereochemical fluxionality of octahedral [Cu(trien)(diimine)]²⁺complexes determines the Cu^II/Cu^Iredox potential, DNA binding affinity, ROS generation, cytotoxicity and apoptosis-inducing ability.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT00928H

Reference94 articles.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

2. Platinum Drug Distribution in Cancer Cells and Tumors

3. A randomised multicentre phase II study with cisplatin/docetaxel vs oxaliplatin/docetaxel as first-line therapy in patients with advanced or metastatic non-small cell lung cancer