Molecular dynamics study on the inhibition mechanisms of ReACp53 peptide for p53–R175H mutant aggregation-Reference-Cited by-同舟云学术

Molecular dynamics study on the inhibition mechanisms of ReACp53 peptide for p53–R175H mutant aggregation

Published:2021 Issue:40 Volume:23 Page:23032-23041
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Lei Jiangtao¹^ORCID,Cai Mengqiang¹,Shen Yun²,Lin Dongdong³^ORCID,Deng Xiaohua¹

Affiliation:

1. Institute of Space Science and Technology, Nanchang University, Xuefu Avenue 999, Nanchang City 330031, China

2. Department of Physics, School of Sciences, Nanchang University, Xuefu Avenue 999, Nanchang City 330031, China

3. Department of Physics and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang City 315211, China

Abstract

p53 mutant aggregation can lead to loss-of-function (LoF), dominant-negative (DN) and gain-of-function (GoF) effects, involved in tumor growth.

Funder

National Natural Science Foundation of China

Nanchang University

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP03094A

Reference70 articles.

1. Structural diversity of dimers of the Alzheimer amyloid-β(25–35) peptide and polymorphism of the resulting fibrils

2. Alzheimer disease

3. Folding and misfolding of alpha-synuclein on membranes

4. In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy

5. Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advanced computational approaches to understand protein aggregation;Biophysics Reviews;2024-04-24

2. Oncogenic R248W mutation induced conformational perturbation of the p53 core domain and the structural protection by proteomimetic amyloid inhibitor ADH-6;Physical Chemistry Chemical Physics;2024

3. Elucidating the Mechanisms of R248Q Mutation-Enhanced p53 Aggregation and Its Inhibition by Resveratrol;The Journal of Physical Chemistry B;2023-09-04

4. Mechanistic insights into the allosteric inactivation mechanism of ZAP-70 induced by the hot spot W165C mutation;Journal of Biomolecular Structure and Dynamics;2023-07-28

5. Targeting p53 pathways: mechanisms, structures, and advances in therapy;Signal Transduction and Targeted Therapy;2023-03-01