Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions-Reference-Cited by-同舟云学术

Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions

Published:2022 Issue:19 Volume:20 Page:3907-3912
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bhukta Swadhapriya¹^ORCID,Chatterjee Rana¹^ORCID,Dandela Rambabu¹^ORCID

Affiliation:

1. Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Indian Oil Odisha Campus, Samantpuri, Bhubaneswar 751013, India

Abstract

Iodine and TBHP promoted facile synthesis of α-ketoamides has been developed from vinyl azides. A variety of α-ketoamides including a Ceritinib cancer drug derivative were obtained in a high yield under mild conditions.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00458E

Reference62 articles.

1. Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

2. α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

3. Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides