X-ray structural, functional and computational studies of the O2-sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe

X-ray structural, functional and computational studies of the O2-sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe–4S] cluster

Published:2018 Issue:52 Volume:54 Page:7175-7178
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Volbeda A.¹²³⁴⁵^ORCID,Mouesca J. M.⁶⁷⁸⁹^ORCID,Darnault C.¹²³⁴⁵,Roessler M. M.¹⁰¹¹¹²¹³^ORCID,Parkin A.¹⁰¹¹¹²¹³^ORCID,Armstrong F. A.¹⁰¹¹¹²¹³^ORCID,Fontecilla-Camps J. C.¹²³⁴⁵^ORCID

Affiliation:

1. Univ. Grenoble Alpes

2. CEA

3. CNRS

4. IBS

5. F-38000 Grenoble

6. CEA-Grenoble/INAC/SyMMES/CAMPE

7. UMR SyMMES 5819 (CEA-CNRS-UGA)

8. F-38054 Grenoble

9. France

10. Univ. Oxford

11. Dept. Chem

12. Oxford OX1 3QR

13. UK

Abstract

A combined experimental and computational study of an O₂-tolerant [NiFe]-hydrogenase mutated proximal FeS cluster with possible applications to similar problems.

Funder

Agence Nationale de la Recherche

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Centre National de la Recherche Scientifique

Université Grenoble Alpes

Biotechnology and Biological Sciences Research Council

Merton College, University of Oxford

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC02896F

Reference29 articles.

1. Oxygen-tolerant hydrogenases in hydrogen-based technologies

2. Characterization of a unique [FeS] cluster in the electron transfer chain of the oxygen tolerant [NiFe] hydrogenase from Aquifex aeolicus

3. A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase

4. Oxygen-Tolerant [NiFe]-Hydrogenases: The Individual and Collective Importance of Supernumerary Cysteines at the Proximal Fe-S Cluster

5. The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre

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