The impact of α-hydrazino acids embedded in short fluorescent peptides on peptide interactions with DNA and RNA-Reference-Cited by-同舟云学术

The impact of α-hydrazino acids embedded in short fluorescent peptides on peptide interactions with DNA and RNA

Published:2016 Issue:21 Volume:14 Page:4865-4874
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Suć Josipa¹²³⁴,Tumir Lidija-Marija¹²³⁴,Glavaš-Obrovac Ljubica⁵⁶⁷⁴,Jukić Marijana⁵⁶⁷⁴,Piantanida Ivo¹²³⁴,Jerić Ivanka¹²³⁴

Affiliation:

1. Division of Organic Chemistry and Biochemistry

2. Ruđer Bošković Institute

3. 10000 Zagreb

4. Croatia

5. Department of Medicinal Chemistry and Biochemistry

6. School of Medicine Osijek

7. 31000 Osijek

Abstract

The α-hydrazino group in a peptide systematically decreased its fluorimetric response to DNA/RNA binding in the order: mono-hydrazino < alternating-hydrazino < sequential-hydrazino. Two sequential α-hydrazino 3 specific for poly rG.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00425C

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1. Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

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