<i>N</i>-Arylsulfonamide-based adenosine analogues to target RNA cap <i>N</i>7-methyltransferase nsp14 of SARS-CoV-2-Reference-Cited by-同舟云学术

N-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2

Published:2024 Issue:3 Volume:15 Page:839-847
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Ahmed-Belkacem Rostom¹,Troussier Joris¹,Delpal Adrien²,Canard Bruno²,Vasseur Jean-Jacques¹,Decroly Etienne²^ORCID,Debart Françoise¹^ORCID

Affiliation:

1. IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France

2. AFMB, University of Aix-Marseille, CNRS, Marseille, France

Abstract

SAH-derived bisubstrates of SARS-CoV-2 cap RNA N7-methyltransferase were synthesized, and two adenosines with an N-arylsulfonamide core attached by an N-ethylthioether linker proved to be effective inhibitors in the submicromolar range.

Funder

Fourth Framework Programme

Innovative Medicines Initiative

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00737E

Reference45 articles.

1. Chemical biology and medicinal chemistry of RNA methyltransferases

2. Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses

3. Coronaviral RNA-methyltransferases: function, structure and inhibition

4. Druggable targets from coronaviruses for designing new antiviral drugs

5. Biochemical principles and inhibitors to interfere with viral capping pathways

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