Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides-Reference-Cited by-同舟云学术

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kocek Hugo¹²^ORCID,Chalupská Dominika¹,Dejmek Milan¹^ORCID,Dvořáková Alexandra¹,Zgarbová Michala¹³,Šála Michal¹^ORCID,Chalupský Karel¹,Krafčíková Petra¹,Otava Tomáš¹⁴,Drexler Matúš¹^ORCID,Procházková Eliška¹^ORCID,Klepetářová Blanka¹,Štefek Milan¹⁵^ORCID,Kozic Ján¹^ORCID,Mertlíková-Kaiserová Helena¹,Boura Evzen¹,Weber Jan¹^ORCID,Nencka Radim¹^ORCID

Affiliation:

1. Institute of Organic Chemistry, and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic

2. Faculty of Chemical Technology, University of Chemistry and Technology, Prague, Czech Republic

3. Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic

4. Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, Czech Republic

5. Department of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

Abstract

SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides.

Funder

Akademie Věd České Republiky

European Commission

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00422A

Reference46 articles.

1. A new coronavirus associated with human respiratory disease in China

2. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

3. SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

4. Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

5. Innate Recognition of Viruses