Catalyst-free gem-chlorosulfurization of difluoromethyl-substituted diazo compounds with disulfide and PhICl2-Reference-Cited by-同舟云学术

Catalyst-free gem-chlorosulfurization of difluoromethyl-substituted diazo compounds with disulfide and PhICl2

Published:2021 Issue:37 Volume:19 Page:8030-8034
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Jiuling¹²^ORCID,Li Bin²,Chen Juan²,Jia Xinyu²,Wang Min²,Hao Chengjun²,Zheng Xinhua²,Dai Hongmei²,Hu Wenhao¹

Affiliation:

1. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

2. Henan Engineering Research Center of Funiu Mountain's Medical Resources Utilization and Molecular Medicine, School of Medical Sciences, Pingdingshan University, Pingdingshan 467000, China

Abstract

A series of gem-chlorosulfurization products bearing difluoromethyl substituents were synthesized from TsCF2CHN2, disulfides and PhICl2 under mild conditions, which could be efficiently converted to multi-component products by a facile operation.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Guangdong Province Introduction of Innovative R&D Team

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01422F

Reference47 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition