Modulation of cyclic topology toward enhanced drug delivery, from linear and tadpole-like to dumbbell-shaped copolymers

Author:

Kang Guiying1234,Liu Yuping1234,Li Lingxia56783,Sun Lu1234,Ma Wei1234,Meng Chao1234,Ma Liwei1234,Zheng Guohua91011124,Chang Cong91011124ORCID,Wei Hua1234ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry

2. Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University

3. Lanzhou

4. China

5. State Key Laboratory of Veterinary Etiological Biology

6. Key Laboratory of Animal Virology of the Ministry of Agriculture

7. Lanzhou Veterinary Research Institute

8. Chinese Academy of Agricultural Sciences

9. Department of Pharmaceutics

10. School of Pharmacy

11. Hubei University of Chinese Medicine

12. Wuhan

Abstract

We reported herein the synthesis of a novel dumbbell-shaped amphiphilic copolymer with two macrocycles-based bells, and revealed the better performance of this polymer construct than those of the linear and tadpole-like analogues for drug release.

Funder

National Natural Science Foundation of China

Hubei Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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