A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment-Reference-Cited by-同舟云学术

A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

Published:2023 Issue:7 Volume:10 Page:2554-2567
ISSN:2051-6347
Container-title:Materials Horizons
language:en
Short-container-title:Mater. Horiz.

Author:

Zhang Miao¹,Peng Xu²,Ding Yuan¹,Ke Xiang¹,Ren Kai¹,Xin Qiangwei¹,Qin Meng¹,Xie Jing¹^ORCID,Li Jianshu¹³⁴^ORCID

Affiliation:

1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P. R. China

2. Experimental and Research Animal Institute, Sichuan University, Chengdu 610065, P. R. China

3. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China

4. Med-X Center for Materials, Sichuan University, Chengdu 610041, P. R. China

Abstract

It is found that a cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system can effectively treat early OA through synergistic lubrication, dual-drug sequence controlled release, and anti-inflammation.

Funder

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MH/D3MH00218G

Reference65 articles.

1. A Solid–Liquid Composite Lubricating “Nano‐Snowboard” for Long‐Acting Treatment of Osteoarthritis

2. Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression