Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C

Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C–C bond cleavage

Published:2020 Issue:23 Volume:10 Page:13815-13819
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Huang Jiangkun¹²³⁴⁵,Luo Lan¹²³⁴⁵,Xing Naiguo¹²³⁴⁵,Gu Linghui¹²³⁴⁵,Li Chen¹²³⁴⁵,Han Qiao¹²³⁴⁵,Zheng Shilong⁶⁷⁸⁹^ORCID,He Ling¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry

2. Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology

3. Department of Medicinal Chemistry

4. West China School of Pharmacy

5. Sichuan University

6. Department of Chemistry and RCMI Cancer Research Center

7. Xavier University of Louisiana

8. New Orleans

9. USA

Abstract

A one-pot synthesis, initiated by a copper salt with (NH₄)₂CO₃ as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via C–H activation, α-amination and oxidative C–C bond cleavage and condensation cascade reaction.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA01408G

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1. Chiral N-heterocyclic carbenes as stereodirecting ligands in asymmetric catalysis