Development of 8–17 XNAzymes that are functional in cells-Reference-Cited by-同舟云学术

Development of 8–17 XNAzymes that are functional in cells

Published:2023 Issue:28 Volume:14 Page:7620-7629
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chiba Kosuke¹^ORCID,Yamaguchi Takao¹^ORCID,Obika Satoshi¹²³^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

2. National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan

3. Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Abstract

Modified 8–17 DNAzymes that can induce target gene silencing in cells were developed based on the X-ray crystal structure of 8–17 DNAzyme and the modifications used in designing antisense oligonucleotides.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Japan Science Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01928D

Reference46 articles.

1. A DNA enzyme that cleaves RNA

2. A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions

3. DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons

4. A DNA metalloenzyme with DNA ligase activity

5. General Deoxyribozyme-Catalyzed Synthesis of Native 3‘−5‘ RNA Linkages

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