Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands

Author:

Prajapati D.1234,Schulzke C.5678,Kindermann M. K.5678,Kapdi A. R.1234

Affiliation:

1. Department of Chemistry

2. Institute of Chemical Technology

3. Mumbai-400019

4. India

5. Institute fur Biochemie

6. Ernst-Moritz-Arndt Universität Greifswald

7. D-17487 Greifswald

8. Germany

Abstract

A selective palladium-catalysed arylation of 2,6-dibromopyridine has been developed by employing N-heterocyclic carbene ligands. Selective mono-arylation was performed in water/acetonitrile solvent at ambient temperature and low catalyst loading.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference96 articles.

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3. F. Diedrich and P. J.Stang, Metal-catalyzed Cross-coupling Reactions, Wiley-VCH, New York, 1998

4. Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis

5. Palladium-Mediated Total Synthesis of Bioactive Natural Products

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