Design, synthesis, anticancer and in silico assessment of 8-caffeinyl-triazolylmethoxy hybrid conjugates

Author:

Soltani Rad Mohammad Navid1ORCID,Behrouz Somayeh1,Aghajani Saleh1,Behrouz Marzieh1,Zarenezhad Elham2ORCID,Ghanbariasad Ali3

Affiliation:

1. Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, Iran

2. Non-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran

3. Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Abstract

Design, synthesis, anticancer, docking and in silico assessment for 8-caffeinyl-triazolylmethoxy hybrid conjugates are explained. These compounds have remarkable activities against malanoma and breast cancer cell lines.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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4. C. O.Wilson , O.Gisvold and J. H.Block , Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry , ed. J. H. Block and J. M. Beale Jr. , Lippincott Williams & Wilkins , Philadelphia , 11th edn, 2004

5. B. G.Katzung , Basic & Clinical Pharmacology , Lange Medical Publications, McGraw-Hill Companies , 14 edn, 2018

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